IPA 8.7 has new molecular toxicology content.

Next week we'll release IPA 8.7.  New molecular toxicology content will be fully integrated in analysis and exploration workflows within IPA, helping researchers at all phases better understand mechanisms of toxicity.

Release highlights:
  • Significant increase in molecular toxicology content and Findings
    • First of its kind of molecular association to clinical chemistry content
    • Focus on key clinical and pre-clinical pathology endpoints as prioritized by customers across key tissues liver, kidney, and heart
    • Addition of hematology assay content
  • Integrates pathology and clinical chemistry with molecular knowledge
    • Integrate with Tox List knowledge to understand molecular toxicity earlier in the discovery process
    • Integrate with molecular profiles to identify biomarkers for compound screening



Release details:
  • ~15,000 new Findings from ~750 articles on hepatotoxicity and clinical chemistry endpoints
  • New toxicity annotations that describe pathology endpoints and clinical measurements
  • Ten new canonical pathways (cardiovascular-related and cellular immune response and cytokine signaling related)
    • Extrinsic Prothrombin Activation Pathway
    • Intrinsic Prothrombin Activation Pathway
    • Inhibition of Angiogenesis by TSP1
    • P2Y Purigenic Receptor Signaling Pathway
    • Antiproliferative Role of TOB in T Cell Signaling
    • MIF-mediated Glucocorticoid Regulation
    • MSP-RON Signaling Pathway
    • OX40 Signaling Pathway
    • PI3K Signaling in B Lymphocytes
    • Tumoricidal Function of Hepatic Natural Killer Cells
  • 67% increase in number of Tox Lists describing toxicity-relevant gene sets. New lists include:
    • Cardiac Hypertrophy
    • Cardiac Necrosis/Cell Death
    • Liver Necrosis/Cell Death
    • Liver Proliferation
    • Cardiac Fibrosis
    • Renal Necrosis/Cell Death
    • Increases Cardiac Proliferation
    • Increases Bradycardia
    • Increases Heart Failure
    • Increases Liver Damage
    • Increases Liver Steatosis
    • Increases Renal Damage
    • Increases Cardiac Dilation
    • Increases Renal Proliferation
    • Increases Cardiac Dysfunction
    • Increases Glomerular Injury
    • Increases Liver Hyperplasia/Hyperproliferation
    • Increases Renal Nephritis
    • Increases Liver Hepatitis
    • Increases Damage of Mitochondria
    • Increases Dysfunction of Mitochondria
    • Swelling of Mitochondria
    • Increases Transmembrane Potential of Mitochondria and Mitochondrial Membrane
    • Decreases Transmembrane Potential of Mitochondria and Mitochondrial Membrane
    • Increases Permeability Transition of Mitochondria and Mitochondrial Membrane
    • Decreases Permeability Transition of Mitochondria and Mitochondrial Membrane
    • Increases Depolarization of Mitochondria and Mitochondrial Membrane
    • Decreases Depolarization of Mitochondria and Mitochondrial Membrane
    • Biogenesis of Mitochondria
    • Decreases Respiration of Mitochondria



Other Toxicology Resources:

Orange Arrow  Tox Best Practices White Paper
Orange Arrow  IPA Toxicology Bibliography (Tox papers citing IPA)
Orange Arrow  Learn more about toxicology capabilities in IPA

Learn more about IPA on our website, www.ingenuity.com
Click here to register for a free, fully functional two-week trial of IPA.