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This white paper demonstrates how to most rapidly and effectively search the published literature to find relevant search results, generate testable hypotheses, create relevant biological models, and streamline experimental planning.
You’ll learn how the search and explore features in IPA® provides you with direct access to the world's largest knowledge base of detail-rich information on genes, chemicals, cellular and toxicity phenotypes, diseases, pathways, and their interrelationships. The Search capability generates relevant lists of genes and chemicals associated with specific biological functions, pathways, or annotations. Unlike traditional solutions, the resulting lists can then be transformed into fully interactive, literature-supported graphical models of experimental systems using IPA Explore tools such as Grow, Connect, and Path Explorer.
In this paper, IPA's Search function is used to quickly identify genes and chemicals involved in tumor angiogenesis and rapidly flag the subset of druggable tumor angiogenesis genes. Pathway building tools are then applied to examine how tumor angiogenesis genes work together as a molecular module, to identify adjacent signaling and metabolic pathways, and to identify experimental tools and drugs that can be used to perturb those pathways.
You’ll learn how the search and explore features in IPA® provides you with direct access to the world's largest knowledge base of detail-rich information on genes, chemicals, cellular and toxicity phenotypes, diseases, pathways, and their interrelationships. The Search capability generates relevant lists of genes and chemicals associated with specific biological functions, pathways, or annotations. Unlike traditional solutions, the resulting lists can then be transformed into fully interactive, literature-supported graphical models of experimental systems using IPA Explore tools such as Grow, Connect, and Path Explorer.
In this paper, IPA's Search function is used to quickly identify genes and chemicals involved in tumor angiogenesis and rapidly flag the subset of druggable tumor angiogenesis genes. Pathway building tools are then applied to examine how tumor angiogenesis genes work together as a molecular module, to identify adjacent signaling and metabolic pathways, and to identify experimental tools and drugs that can be used to perturb those pathways.
Rapid Generation of Testable Hypothesis & Streamlined Experimental Planning: Search and Explore in IPA
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